TB-500

TB-500 (Thymosin Beta-4) is a 43 amino acid peptide sequence. In animal models, Thymosin Beta-4 has been shown to improve blood vessel growth, regulate wound healing, decrease inflammation, and reduce oxidative damage in the heart and central nervous system. Thymosin-beta-4 has a role in protection, tissue repair, regeneration and remodeling of injured or damaged tissues. It is also of active interest in anti-ageing research.

TB 500 is a synthetic version of TB-4, a peptide naturally present in human and animal cells. Thymosin Beta 4 is crucial for promoting angiogenesis, or the formation of new blood vessels, in dermal tissues.

https://pubmed.ncbi.nlm.nih.gov/6863931/

TB-500 and Rheumatoid Arthritis

A 2017 study explored the rationale and clinical reasons for considering Thymosin Beta 4 (TB-500) as a potential treatment for rheumatoid arthritis (RA). The research found elevated levels of TB-4 in both serum and joint fluid of RA patients.

In summary, the impact of increased TB-4 expression in serum and joint fluid on rheumatoid arthritis patients—whether it is advantageous or detrimental—has yet to be fully determined.

TB-500 and Wound Healing

Research presented at the 7th International Congress of Allergy and Immunology highlights that Thymosin Beta 4 (TB-500) significantly speeds up wound healing in the eye. This effect is achieved through enhanced epithelial migration and reduced inflammation, both of which are crucial for faster and more effective healing.

Additionally, another study indicates that recombinant TB-4 promotes the healing of full-thickness skin wounds in mice. Treatment with Thymosin Beta 4 led to increased re-epithelialization and substantial capillary growth, further supporting its role in wound repair.

https://pubmed.ncbi.nlm.nih.gov/17923415/

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