FOX04-DRI 10mg 

FOXO4-DRI is a synthetic peptide based on a key interaction region of the forkhead box O4 transcription factor, engineered in a D-retro-inverso configuration. It is studied in the context of cellular ageing and senescence, where modulation of FOXO-related pathways and p53 interaction may influence senescent cell survival and selective clearance.

This peptide is produced through controlled laboratory synthesis and is not naturally occurring in this form. Its modified structure is designed to enhance stability and resistance to enzymatic breakdown, allowing researchers to investigate FOXO4-linked mechanisms over extended timeframes in a defined, reproducible way. It is used in projects focused on senescence biology, tissue function and age-related changes in in-vitro models.

Key Features FOXO4-DRI

FOXO4–p53 Pathway Tool – Used to support studies involving FOXO4–p53 interactions and senescent cell regulation

Senescence & Ageing Insight – Suitable for research into senescent cell survival, clearance and tissue ageing

Mechanistic Studies – Selected for in-vitro work on apoptosis signalling and stress-response pathways

Enhanced Stability Design – D-retro-inverso configuration for improved resistance to enzymatic degradation

High Research Purity – Supplied as a lyophilised solid for controlled laboratory use

Research Only – Intended for qualified professionals conducting scientific investigation

Research Context

In experimental settings, FOXO4-DRI is used to explore:

• Cellular senescence and ageing-related signalling cascades

• The role of FOXO4–p53 interaction in senescent cell survival

• Experimental senolytic strategies and selective senescent cell apoptosis

• Chemotoxic and stress models where senescent cell burden is of interest

• Functional outcomes in tissue and organ models linked to senescence markers

Its structured, D-retro-inverso design makes it suitable for in-vitro studies where controlled modulation of FOXO4-related pathways and senescence-associated responses is required, including comparative work alongside FOXO4 and other senescence-focused research tools.

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FOXO4-DRI 10mg

CAS Number	2460055-10-9
Molar Mass	5358.05 g/mol
Molecular Formula	C₂₂₈H₃₈₈N₈₆O₆₄
Chemical Name	FOXO4 D-Retro-Inverso peptide (FOXO4-derived D-isomer sequence)

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